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In GPX4 brain-inducible knockout mouse models, vitamin E deficiency accelerated hippocampal neuronal degeneration and behavioral decline (Wortmann et al., 2013)

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TB-500 operates through G-actin sequestration and PI3K/Akt activation

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Differential activation of creb by ca2+/calmodulin-dependent protein kinases type ii and type iv involves phosphorylation of a site that negatively regulates activity