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Autophagy suppresses tumorigenesis through elimination of p62

(2017) 13:e1006603

As a result, a very small amount reaches the melanocytes in the deep layers of the skin at a concentration high enough to affect melanin production

doi:10.1074/jbc.M112.355172 Wood, J M et al

AlphaFold3-predicted 3D structural modeling suggested that KW substitutions alter both the binding affinity and interaction pattern between HMGB1/2 and Importin Alpha 5 (IMA5, a key nuclear import mediator for HMGB1/2) (Figure S5A-B)