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We also refer to our response to comments in earlier rulemaking (see 88 FR 77184 through 77185) in which we explained that the Shared Savings Program's benchmarking methodology has the potential to mitigate the differences between the 340B-acquired drug payments included in historical benchmark year and performance year expenditure calculations, among other considerations with respect to how the payments amounts would be considered in Shared Savings Program calculations

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This intriguing observation suggests the involvement of intricate transcriptional regulatory mechanisms governing MTs genes

Evaluation of a murine liver colonization model revealed that PKLR promotes cell survival in the tumor core during conditions of high cell density and oxygen deprivation by increasing glutathione, the primary endogenous antioxidant