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The roots, leaves, and basal stem of this plant contain various alkaloids, including the well-known chemically used anti-carcinogenic alkaloids vinblastine, vindoline, vindolidine, vindolicine, vindolinine, vindogentianine, and vincristine (9)

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Plant Biotechnol J 15:271284

244247] As to dose, there are multiple considerations: Adding an appropriate supportive dose without overdosing Assuring cofactor availability Form of glutathione supplement and bioavailability My recommendations generally are to have intake of a supplement with trace elements and other minerals like magnesium, a prenatal supplying the b-vitamin cofactors, and assuring at least 200-600 IU of tocopherols (depending on form)

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Traditional Chinese medicines Traditional Chinese medicine (TCM) has a long history in treating DKD, either alone or in combination with conventional drugs like ACEI/ARBs, showing positive therapeutic effects [109, 110]