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So at least in my case, and again, this is anecdata, it seemed to

Weber EJ, Himmelfarb J, Kelly EJ (2017) Concise review: current and emerging biomarkers of nephrotoxicity

J Biol Chem (2009) 284(1):15

Sterol feedback regulation is characteristic of all genes involved in cholesterol biosynthesis and homeostasis, whereas cAMP-dependent regulation is unique, suggesting that CYP51A1 may play a tissue-specific role distinct from cholesterol biosynthesis

Therapeutic approaches to augment frataxin production or modulate mitochondrial malfunctioning, increase ROS production, and Nrf2 activation have been used in phase II clinical trials ( FXN knockdown human astrocytes resulted in increased neuron viability, neurite length, and synapse formation when these cells were injected into the mice brain ( FXN mRNA levels