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doi: 10.1038/s41598-020-73321-8 209 WangP.ChenZ

Infusion supply of Klotho protein during IRI significantly reduced the level of phospho-IGF1R ( p = 0.0436), PI3K ( p = 0.0218) and phospho-AKT ( p = 0.0020)

For improved outcomes, more injections will be required

For example, inhaled drugs directly targeting the lung epithelium may be more effective in treating ALI of pulmonary insults, whereas intravenous injection to quench inflammatory responses at the pulmonary capillary endothelium may be more effective in treating ALI of extrapulmonary origin