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Consequently, NPTA construction requires long-term in vivo tracking of biodistribution, metabolism, and excretion of NPTAs and their metabolites, alongside comprehensive analysis of multi-organ functional impacts

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Methods: We systematically retrieved data from PubMed, Web of Science, ScienceDirect, SciFinder, Scopus, and the China National Knowledge Infrastructure (CNKI) spanning database inception to March 2025, followed by taxonomic integrative analysis of NPs and antitumor compounds echanistic classifications