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In addition, melatonin inhibits cytokine expression in cells treated with lipopolysaccharide (LPS) (100)

Med Res Rev 24: 4089

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David, E

Hypoxia can induce endothelial cells to release more contractile mediators like endothelin-1 and platelet-activating factor to vascular smooth muscle cells, while decreasing the production of relaxing mediators such as nitric oxide (NO) and prostaglandins