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The major sources of free radicals include: Ordinary body functions, such as breathing and digestion Exposure to radiation Exposure to other environmental pollutants Consumption of cigarettes, tobacco, drugs and alcohol Certain medications or high use of antibiotics, which leads to antibiotic resistance A poor diet that includes foods like unhealthy fats, too much sugar, pesticides, herbicides or synthetic additives

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P., Munji, R

2016;4:e1251384

Human participants Serum zonulin levels were analyzed by ELISA (Cusabio Technology LLC, USA) and compared in cross-sectional manner in two cohorts: (i) 41 healthy female controls, 65 female predisease patients and 40 female RA patients from the Department of Internal Medicine 3 of the University of Erlangen-Nrnberg/Germany as well as (ii) 11 healthy female controls, 21 female predisease patients and 28 female RA patients from the Department of Rheumatology & Immunology of the West China Hospital in Chengdu/China