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160 developed a method for the simultaneous determination of 11 opioids and 4 metabolites (buprenorphine, codeine, fentanyl, hydromorphone, methadone, morphine, oxycodone, oxymorphone, piritramide, tilidine, tramadol and their metabolites bisnortilidine, nortilidine, norfentanyl and normorphine) in hair samples

For patients whose CaP recurs after such treatments or who present with CaP that is already too advanced to benefit from these treatments, androgen deprivation therapy (ADT) remains the cornerstone in their treatment plans [3, 4]

Abstract Trimethylamine N-oxide (TMAO), a key metabolite derived from the gut microbial metabolism of choline, has recently been implicated as a significant contributor to the development of several chronic diseases, including diabetes, cardiovascular disease, and chronic kidney disease