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Bile acids have cytotoxic effects that activate HSCs and stimulate the secretion of profibrogenic mediators, such as transforming growth factor beta, reactive oxygen species, TNF-, and platelet-derived growth factor (Waisbourd-Zinman et al., 2016)

the transient expression of LePHGPX in these stress-exposed leaves prevented DNA fragmentation and maintained membrane integrity

Targeting the catalytic action of DPP-4 with inhibitors is also effective in the treatment of T2DM

doi: 10.1016/j.tox.2017.07.016 139 ZhangQRaoofMChenYSumiYSursalTJungerWet al

Carbon 55 , 321327 (2013)

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