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Altogether, C3G was predicted as mh-Tyr alternative substrates which exhibit rapid oxidation, and hence, served as a weak competitive inhibitor by comparison to EC and CH compounds

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For medicinal plants such as Astragalus , which are stress-sensitive and rely on specific secondary metabolic networks to sustain quality, the underlying regulatory mechanisms by which SL mediates functional reconstruction of damaged tissues, particularly regarding how transcriptome-metabolome crosstalk is associated with the recovery of protein translation machinery and metabolic networks, remain largely elusive ( Astragalus via morphological and physiological trait detection combined with whole-transcriptome sequencing integrated with the WGCNA method

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Excessive ROS triggers oxidative stress Although ROS production in mitochondria is in balance with an intracellular antioxidant system under physiological conditions, the balance is easy to be disrupted under pathological conditions, such as radiation, hypoxia, cytokines, hyperlipidemia, and hyperglycemia, which results in the accumulation of ROS, facilitating oxidative stress, cell damage, and diseases, such as cancer, cardiovascular disease, neurological disease, respiratory disease, and so on