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In targeted protein degradation (TPD) technologies, small-molecule degraders typically act through either the ubiquitinproteasome system (UPS) or the lysosomal pathway

Currently, the most common presentation is an asymptomatic patient with persistently elevated levels of alkaline phosphatase first noted on routine serum biochemical screening

This makes the toxin water-soluble, allowing the body to flush it out through urine or bile

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That preservative is the reason you can open the same vial, use a little, and come back to it over the following weeks instead of throwing it out after one use