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However, most mechanistic evidence for legume polyphenols is derived from in vitro and animal studies, while human health effects are primarily mediated by circulating conjugated and microbiota-derived metabolites formed at physiologically achievable dietary intakes

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La tiamina o vitamina B1 en forma de tiamina pirofosfato es cofactor de componente E1 de complejo de piruvato deshidrogenasa donde cataliza descarboxilacin de piruvato generando hidroxietil-TPP que subsecuentemente transfiere grupo acetilo a lipoamida en componente E2, haciendo que tiamina y cido alfa lipoico trabajen secuencialmente en mismo complejo enzimtico

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Obes Rev 12(7)