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Our data suggest that O-GlcNAcylation of Ezh2 and/or other co-factor(s) contributes to define the repertoire of Ezh2 targets in liver cancer and provide important insights for epigenetic strategies as potential future anti-HCC therapies

Immune aging in multiple sclerosis is characterized by abnormal CD4 T-cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age

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Deuxiemement, une interaction avec le systeme opioidergique endogene : le DSIP modifie la reactivite aux agonistes opioides sans etre lui-meme opioide, ce qui a ete interprete comme une action allosterique ou indirecte