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10.1371/journal.pone.0162133 28 FletcherS.ProchownikE

6 Peptides and proteins have large molecular weights (MW) and tend to be highly polar, features that mitigate against intestinal transepithelial flux

If you are experiencing concerning side effects or need to discontinue tirzepatide for medical reasons (such as upcoming surgery or pregnancy), the most appropriate approach is to simply stop taking the medication and allow natural elimination to occur over the expected 3-to-4-week timeframe