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Additional file 11: Figure S11

What Patients Evaluating AOD 9604 Typically Report Timeline to first changes: Most published protocols note 4 to 6 weeks before body composition changes become measurable Areas of change: Visceral and subcutaneous fat reduction, with particular effect reported in the abdominal region in some subjects Energy and recovery: Some participants in clinical and investigational settings report improved energy and exercise recovery, though this is not a primary mechanism of the peptide What it is not: AOD 9604 does not cause rapid dramatic weight loss the way GLP-1 medications can in the first few months

To investigate the neural mechanisms of Cagrilintide, next-generation sequencing (NGS) was performed on three key hypothalamic and brainstem regions: the area postrema/nucleus tractus solitarius (AP/NTS), lateral parabrachial nucleus (LPBN), and ventromedial hypothalamus (VMH)

J Exp Med (1997) 186(7):114958

Olivito I, Avolio E, Minervini D, Soda T, Rocca C, Angelone T, et al

J Biomed Mater Res A 93(4):15391550 Salehi Z, Hadiyan SP, Navidi R (2013) Ciliary neurotrophic factor role in myelin oligodendrocyte glycoprotein expression in Cuprizone-induced multiple sclerosis mice