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IG, SL and KE performed the experiments

Acknowledgements We thank Bullet Edits Limited for the linguistic editing of the manuscript

Figure 6 3.5 CircRNA bioinformatics CircRNA (Circular RNA) has the characteristics of being abundant, evolutionarily conserved, and relatively stable in the cytoplasm, which enables it to have many functions and participate in gene expression regulation through various ways of action (21)

Nonetheless, research about the role of PCP in ototoxicity and its implications for the MET channel's gating dynamics is limited, highlighting an area ripe for scientific inquiry and breakthrough

Additionally, oxidative stress plays a significant role in the initiation and development of cancer by causing DNA damage, disrupting apoptosis mechanisms, and promoting immune evasion

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