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Similarly, models with significant kidney or liver dysfunction are generally unsuitable, as impaired peptide clearance may heighten the risk of adverse effects

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During DNA replication, DNA polymerase misincorporates thymine (T) opposite O 6 -MeG, rather than cytosine (C), which is the correct partner for guanine.Normal cells typically contain a greater number of G-C base pairs than malignant cells, a phenomenon attributed to the mispairing of O 6 -MeG with thymine, which leads to a reduction in methylatable cytosine residues

Seveau, S., Bierne, H., Giroux, S., Prevost, M