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Concentration levels remained at therapeutic levels for 2 to 5 months on average, depending on the dosage administered (100 or 300 mg, respectively) After achieving steady state, patients discontinuing SUBLOCADE may have detectable plasma and urine levels of buprenorphine for 12 months or longer Withdrawal of a partial agonist is typically milder than that of a full agonist and may be delayed in onset Due to the longacting nature of SUBLOCADE, withdrawal signs and symptoms may not be evident immediately following discontinuation

The senescent levels of PDL3 and PDL9 chondrocytes were assessed by senescence-associated beta-galactosidase (SA--gal) staining and qRT-PCR analysis of senescence-associated marker genes