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Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

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The majority of this evidence comes from in vitro fibroblast cultures and animal work

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These findings suggest that trained immunity contributes to neuroinflammation and neurodegeneration in AD

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In a chronic stress model, morin treatment improved levels of key neurotransmitters (epinephrine, norepinephrine, and 5-HT) and reduced inflammatory markers including tumor necrosis factor-alpha, toll-like receptor-4, NOD-like receptor pyrin domain-containing protein-3, interleukin-1beta, and caspase-1 levels, as well as the status of the critical apoptotic marker, caspase-3 in the brain

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