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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

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Furthermore, the location of the GSH density in the present study is clearly supported by mutagenesis data of residues suggested to contact GSH (Table 1)

Glutathione therapy promotes a brighter, more even skin tone by regulating melanin production and supporting cellular regeneration

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