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Although everolimus promoted the recovery of lung function in a phase II clinical trial evaluating the effectiveness of everolimus as HDT in the treatment of TB (96), further preclinical and clinical studies are needed to determine the safety and scope of its use as HDT for TB

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It has also been demonstrated that reduced epidermal thickness, cell damage, impaired barrier function and altered surface characteristics were found in human organ-skin models constructed with premature senescent fibroblasts (80)

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Despite some potentially fatal side effects, the major failures of current cancer treatments are the lack of response in certain human cancer types and tumor relapse after initial remission [1]

Tags are also used to visualize target proteins, either in cells or in test tube (in vitro) experiments