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Hernandez S et al (2008) ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile

Patience and commitment are essential, but the results are worth it

Note that fructose 1-phosphate is present in the hepatocyte only when fructose is metabolized

Regardless of the use of multiple off label therapies, participants living with PBC globally had evidence of ongoing moderatesevere pruritus, underscoring the unmet need for a symptom-specific therapy targeting pruritus in PBC