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Description

Modulation of NF-B signaling levels lies both in the diversity of intermediates driving IKKc activation and the regulated expression of antigens, TNFRs, and cytokine receptors

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One active area of studies involves the use of SMAC mimetics, inhibitors of the E3 ligase c-IAPs that induce accumulation of NIK [42, 43, 161] (Fig

For instance, clinical trials have demonstrated that FMT can improve ICI response rates by modulating immune activation pathways, including NF-B [24, 26]