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In addition, excessive inflammation can interfere with adult neurogenesis, particularly in the hippocampus, a brain region critical for learning and memory [75]

In contrast to mutations in SLC39A8, mutations in the Mn importer SLC39A14 lead to the accumulation of Mn in the brain and in various other extrahepatic tissues, which is characterized by neurological deficits, motor dysfunction, and gastrointestinal damage 48,49,50,51

doi: 10.1016/0092-8674(93)80066-N 23 KalyanaramanB.Darley-UsmarV.DaviesK

This accumulation exacerbates axonal degeneration by overproducing reactive oxygen species (ROS) and releasing pro-apoptotic factors [25, 26]

By eliminating senescent cells, FOXO4-DRI treatment appears to create a more permissive environment for endogenous stem cell activation and tissue renewal, contributing to improvements in organ function and physical capacity

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