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Phase II trial of arsenic trioxide in patients with metastatic renal cell carcinoma

Protein oxidation can result in amino acid modifications (oxidative protein modification), accumulation of cross-linked reaction products, peptide chain fragmentation, and augmented electrical charges (Parthasarathy et al., 1999

This may incite complement, supported by an increased frequency of C4 and C1q deposition and IgG1-predominant antibodies within immune complexes in Hg-induced MGN [44]