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Methionine shortage extends mouse lifespan by 45%, lowers visceral fat and age-related diseases, and prevents lens degeneration [40,41]

Some users report better subjective results with subcutaneous AOD 9604 than the oral formulation used in trials, but controlled data supporting those anecdotal reports does not exist at a level that would change the fundamental comparison

doi: 10.1002/anie.201000044 4 SwallahMSSunHAffohRFuHYuH

doi: 10.1038/nature18930 [DOI] [PMC free article] [PubMed] [Google Scholar] 47

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In addition, they have shown reproducible efficacy in vivo and have progressed into evaluation through clinically relevant delivery systems , including ethosomes, nanoemulsions, and nanogels [37, 39]