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A key part of medicinal chemistry programs is identifying the metabolic liabilities on the drug positions that are metabolized

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VanWagner 5 , Anthony Borgmann 3 , Deepak Gupta 3 , Nikhilesh Mazumder 6 , Justin Richard Boike 1 and Manhal Izzy 3 , (1)Northwestern Memorial Hospital/Northwestern University, (2)Northwestern University, (3)Vanderbilt University Medical Center, (4)Vanderbilt University, (5)University of Texas Southwestern Medical Center, (6)University of Michigan Hospitals and Health Centers, Ann Arbor, MI Background: Heart failure (HF) after Transjugular Intrahepatic Portosystemic Shunt (TIPS) occurs in up to 20% of patients within the first year

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