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It is currently unclear how the I148M variant evades ubiquitination, however targeting the UPS pathway (74, 136), or preventing LD accumulation of PNPLA3 could be potential therapeutics for FLD

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[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Ruf, S

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As shown in Figure 2, NNMTs influence on obesity predominantly stems from its regulatory role in energy metabolism, particularly through NAM methylation, which significantly impacts energy modulation