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Hence, instead of positively transmitting a Ca2+ signal, some types of protein phosphatase such as PP2C act as a negative regulator of ABA signaling (Leung et al., 1994

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Paracrine factors such as IGF-1, HGF and VEGF directly activate PI3KAkt and inhibit intrinsic apoptosis [27], while exosomal miR-21, miR-144-3p and miR-126 down-regulate PTEN , MAP3K9 and other DDR amplifiers, reinstating controlled follicle activation and reducing oxidative phosphorylation overload [21, 25, 62]