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Some common signs of B12 deficiency include fatigue, weakness, pale skin, shortness of breath, dizziness, tingling or numbness in the hands and feet, difficulty walking, memory problems, and mood changes

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The 90-degree angle (straight in) is appropriate when adequate tissue depth is present and no pinch is needed

Nausea affects many patients initially but typically improves within 4-8 weeks

Office of Dietary Supplements (ODS)

A 2022 study involving patients with fibromyalgia found that a short course of sublingual vitamin B12, 1,000 mcg daily, significantly improved the severity of fibromyalgia symptoms as well as the patient's anxiety 8