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Refrigeration dampens molecular motion, essentially putting degradation reactions into slow motion rather than stopping them completely

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Interestingly PUMA interacts with HER2 and is phosphorylated at Y152 and Y172 this phosphorylation increased degradation of the protein and reduces apoptosis induction ( BAX/BAK BAX and BAK form pores in the outer mitochondrial membrane and drive mitochondrial permeabilization (Wei et al., 2001

However, as in the case of LC, in these other post-infectious subgroups of ME/CFS, EBV could also play a possible role in immunological alterations and symptomatology, since the virus is present in 90% of the population [170] and therefore could be reactivated in the presence of immunosuppression [128130, 133140]