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The consequent impact on spermatogenesis is profound, resulting in significantly reduced sperm count, motility, and increased sperm abnormalities and DNA fragmentation, which collectively impair fertilization potential and embryo development 11

Importantly, in the pancreatic cancer subgroup, a median overall survival (OS) of 10.7 months was observed, exceeding historical benchmarks for gemcitabine-based regimens (8.510.1 months) ( In the randomized phase II trial conducted by Jameson et al

The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological, biochemical, and DNA anbormalities