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Conversely, attaching PEG at solvent-exposed regions away from the active site can enhance pharmacokinetics without compromising function.[8] Other challenges of Peptide PEGylation Monodisperse vs

Spread from injection site: Postmarketing reports indicate that the effects of Botox and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects In unapproved uses, including spasticity in children, and in approved indications, cases of spread of effect have been reported at doses comparable to those used to treat cervical dystonia and upper limb spasticity and at lower doses. -Botox boxed safety sheet Literature on use and benefits The Use of Botulinum Toxin for Treatment of Spasticity: A review of how Botox reduces spasticity but may have variable effects on voluntary movement, and considerations on improving efficacy

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Amino Acids, 43 (1), 2537

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Timelines vary by person, goal, and the tissue involved, and no result is guaranteed