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However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]

Furthermore, we note Y211C/H are variants associated with SPCDchanges that likely causes large structural perturbation of the carnitine-binding site beyond simply affecting solvent structure

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