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"Pine Ridge Indian Reservation Struggles With Suicides Among Its Young"

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Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair ( During the proliferative phase of healing, E2 induces the expression of pro-angiogenic factors such as VEGF and PDGFA in endothelial cells to promote angiogenesis (Toutain et al., 2009