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Acknowledgments We are grateful to the Research Center of Clinical Epidemiology (Peking University Third Hospital, China) for supporting our study

Moreover, simvastatin also enhances ex vivo the tumor cell inhibition effects of cisplatin or docetaxel in head and neck squamous carcinoma (HNSCC) (227) and sensitized human osteosarcoma cells to doxorubicin and cisplatin (228)

How far have we come with treatment for the disease

However, ICIs have shown limited efficacy in treating PDAC, predominantly because of the hostile TME characterized by fibrosis, hypoxia, and immunosuppression [148]