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Additionally, ROS-induced AhR signaling can either activate the NLRP3 inflammasome, 211 or inhibit macrophage pyroptosis by upregulating ornithine decarboxylase 1 (Odc-1), enhancing polyamine biosynthesis (e.g., spermine), which suppresses K + efflux and inflammasome assembly, as observed in ulcerative colitis patients 212 (Fig

It has been indicated that prolonged administration of MSG (4 mg/g) significantly induces apoptosis in a time- dependent manner in the rats thymocyte cells via disturbing the fine balances between prooxidant-antioxidant system, with excessive production of ROS and resulting oxidative stress status [46]

2020 Aug 26 [cited

Alcohol Too much alcohol is toxic to the body and can make it more difficult for your liver to process other toxins

Renal impairment : L-carnitine is renally excreted, and accumulation may occur in kidney disease

The bacterial suspension was serially diluted after being resuspended in sterile PBS, and 100 l bacterial solution was taken into 900 l BHI broth containing 10 mM H 2 O 2 , 10 mM FeCl 3 , and 5 mM CuSO 4 for 1 h, respectively