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Ginsenoside Rd protects neurons against glutamate-induced excitotoxicity by inhibiting ca(2+) influx

In addition, recent work suggests that a number of stress paradigms applied to mice early in life leads to reduced concentration of metabolites produced and stored in neurons, namely glutamate, GABA and N -acetylaspartate, almost exclusively in the prefrontal cortex ([77] and references therein)