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Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

The liver, which is the main organ for drug metabolism, is at a particular risk of adverse effects with respect to herbal and nutraceutical agents subject to extensive hepatic biotransformation or induction/inhibition of cytochrome P450 (CYP) enzymes (212)

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ALDH7A1 gene mutation and epilepsy The ALDH7A1 gene, located on chromosome 5q23.2, encodes antiquitin, which is responsible for catalyzing the dehydrogenation of -aminoadipic semialdehyde (-AASA)/piperideine 6-carboxylate (P6C)

Paracrine senescence of mesenchymal stromal cells involves inflammatory cytokines and the NF-B pathway