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The enzyme is found primarily in mast cells, neurons, basophils, and cells lining the stomach.[ref] Genetic variants in the HDC gene affect the susceptibility to Tourettes syndrome and heart disease

After manual exclusion of doublets and dead cells, t-stochastic neighbor embedding (t-SNE) analysis was applied to reduce dimensionality

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Accumulation of orotic acid is used as a clinical indicator of pyrimidine deficiencies or deficiencies in the urea cycle

Acta Pharm Sin B 11(8):23062325 Misra A, Ganesh S, Shahiwala A, Shah SP (2003) Drug delivery to the central nervous system: a review