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Activation of the IRE1-XBP1 pathway is essential for ER expansion and antibody secretion in plasma cells, further implicating ER stress in SLE pathogenesis

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In mice with intestinal dysbiosis, KCs induce NKT cell overactivation, leading to increased IFN- levels through enhanced IL-12 expression, ultimately inhibiting effective liver regeneration after PHx

2.2 Major physiological changes to account for the disease pathology of -synuclein Misfolding of -synuclein has been linked to a plethora of cognitive ailments arising from the death of dopaminergic neurons and collectively referred to as synucleinopathies