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Pakistan Journal of Biochemistry & Molecular Biology

GHK-Cu acts at the extracellular matrix (ECM) level, modulating the balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) to regulate collagen turnover, and stimulating fibroblasts to produce collagen type I, collagen type III, and elastin

The route and dosage of supplementation depend on the severity of deficiency, presence of neurological symptoms, and underlying cause of the deficiency