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The FDA also looked at postmarket safety data from Japan, where the drug was launched in 2020

doi: 10.1158/1078-0432.CCR-08-0024

Psoriasis is a chronic autoimmune disorder which causes an unusual buildup of skin cells

The current study demonstrates that microglial activation and consequent neuroinflammation remain primary initiators and participants in the onset and progression of neurodegenerative diseases [183]

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It demonstrates high solubility in polar organic solvents such as methanol, ethanol, and acetone, while its solubility is significantly reduced in weakly polar organic solvents like chloroform or ethyl acetate (Tan et al., 2020)