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For example, several studies in pediatric renal transplantation have demonstrated the use of 3D-printed models for selecting suitable anastomotic sites and characterizing vascular anomalies that can result in clinical benefits including reduced allograft warm ischemia time and intraoperative blood loss.[78][79] Surgeons can utilize 3D printing with patient-specific measurements to design individualized medical implants such as customized Nuss bars for treating pectus excavatum deformities.[80][81] This technology has also evolved to include bioprinting scaffolds for cell seeding to aid in tissue regeneration, which has begun to show early promise for diseases including esophageal atresia in animal models.[82][83] For all levels of surgical trainees, 3D-printed models have similarly demonstrated potential for advancing education in both hands-on training and simulation for pediatric surgical procedures such as laparoscopic choledochal cyst excision[84] and pyloromyotomy[85]

The processes by which biochemical reactions alter drugs within the body are collectively called drug metabolism or drug biotransformation

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doi:10.1016/j.cell.2021.08.017