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Thus unlike the cytosolic labile iron pool where the redox state of iron is buffered in the iron(II) state by glutathione, in aerobic cells cytosolic heme will be rapidly converted to hematin in the presence of physiological levels of glutathione

Q.et al (2022)

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Therefore, the autophagy pathway plays a double-edged sword in AD pathogenesis

Clin Pharmacol Ther 27(3):301312 Greenblatt DJ, Abernethy DR, Matlis R, Harmatz JS, Shader RI (1984) Absorption and disposition of ibuprofen in the elderly

SN: serial number, RCT: randomized controlled trial, 8-OHdG: 8-hydroxy-2 -deoxyguanosine, IMI: iopathic male infertility, UMI: unexplained male infertility, RPL: recurrent pregnancy loss, ROS: reactive oxygen species, N/A: not available, MDA: malondialdehyde, TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling, SDF: sperm DNA fragmentation, ICSI: intracytoplasmic sperm injection, DFI: DNA fragmentation index, OS: oxidative stress, SOD: superoxide dismutase, GSH: gluthatione, TAC: total antioxidant capacity, SCSA: sperm chromatin structure assay, CoQ: coenzyme Q, FSH: follicle-stimulating hormone, LH: luteinizing hormone, IVF: in vitro fertilization, -HCG: beta-uman chorionic gonadotropin, OAT: oliasthenoteratozoospermia, PRL: prolactin, TSH: thyroid-stimulating hormone, ART: assisted reproductive techniques, TBARS: thiobarbituric acid reactive substances, GPx: glutathione peroxidase, PRM: protamine, CMA3: chromomycin A3