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Severe ASD has been linked to elevated levels of IL-1 and IL-4 in the neonatal blood (Theoharides et al., 2016), and increased serum levels of IL-1 and IL-6 compared to control groups ( Recent data support findings that immune cells activity in ASD subjects is compromised, with amplified inflammatory signaling and reactivity of immune cells such as B-cells, neutrophils and monocytes (Majerczyk et al., 2022)

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Additionally, increased iron storage levels in macrophages are believed to correlate with macrophage polarization, which further influences airway inflammation and the progression of fibrosis [37]

TRAF7 also shortens the circadian period, underscoring its broader role in shaping clock dynamics (Masuda et al., 2024)

It was also reported in DRG neurons of wild type and TRPV4 knockout mice that activation of TRPV4 by paclitaxel induced mechanical allodynia and excessive ROS production, although the allodynia and oxidative stress was partially decreased by the TRPV4 antagonist treatment (Materazzi et al., 2012) (Table 1)

For our studies, we used the gene expression results from 50%