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The pigmentation of blue light is mediated by both melanogenesis activation and autophagy inhibition through OPN3-TRPV1

Either Trx and TrxRD are expressed as isoforms for both predominantly cytosolic (Trx1 and TrxRD1) or mitochondrial (Trx2 and TrxRD2) localization (Orrenius et al., 2007)

Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake

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