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The heart rate increase is progressive, typically adding 1 to 2 beats per minute with each dose escalation step

The synthetic mRNA construct of claim 1, wherein the mRNA construct contains a 5' UTR selected from the group of ATIG, HHV, Human Albumin, Mouse beta globin, SynK, and Truncated Rossi, and a 3' UTR selected from the group of Alanine aminotransferase 1, ARC3-2, Human alpha globin, Human antithrombin, Human apolipoprotein E, Human beta globin, Human complement C3, Human Fibrinogen alpha chain, Human growth factor, Human haptoglobin, Human hepcidin, MALAT, Mouse Albumin, Mouse beta globin, and Xenopus beta globin

The exception is peptides containing copper, like GHK-Cu , which naturally has a blue tint

In certain embodiments, the number of (sub)selected target sites needed to treat a population of a given size is estimated

A study published in the Journal of Clinical Endocrinology found that GH responses to GHRP-6 are much greater than to GHRH in late adulthood